Hydrodynamically balancing oral drug delivery system

Details Hydrodynamically balancing oral drug delivery system Hydrodynamically balancing oral drug delivery system

A - Human Necessities

61

K

A61K 9/46 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2378468

The present invention relates to a gastro-retentive oral drug delivery system comprising a highly porous matrix comprising at least one drug substance, sugar(s), gas generating components and optionally, pharmaceutically acceptable auxiliary components. The pharmaceutical composition, either in the form of pellets (multiparticulate or single unit dosage form), beads, granules or capsules, is retained in the stomach while selectively delivering the drug(s) at gastric levels and upper parts of the small intestine over an extended period of time.

L'invention concerne un système d'administration de médicament par voie orale à rétention dans l'estomac. Ce système comprend une matrice hautement poreuse contenant au moins une substance pharmaceutique, du (des) sucre(s), des composants produisant du gaz et, éventuellement, des composants auxiliaires pharmaceutiquement acceptables. La composition pharmaceutique, sous la forme de pellets (formes à dosage unique ou à particules multiples), de billes, de granules ou de capsules, est retenue dans l'estomac et administre de manière sélective le(s) médicament(s) à des niveaux gastriques et dans des portions supérieures de l'intestin grêle pendant un laps de temps assez long.

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