A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/44 (2006.01) A61L 27/36 (2006.01) A61L 27/38 (2006.01) A61L 27/52 (2006.01)
Patent
CA 2513055
Disclosed are methods and compositions useful in the treatment, augmentation and/or repair of soft and/or hard tissues of animals, and in particular, vertebrates such as humans. The invention provides hydrogel compositions for use in the preparation of medicaments for wound healing, cartilage and meniscus repair, dermal augmentation, and bone fusion, as well as methods for the treatment of intervertebral disc impairment. In particular embodiments, the invention provides compositions useful in restoring hydrodynamic function, increasing intervertebral disc height, and improving proliferation and survival of chondrocytes and other cells in intervertebral discs that have been compromised by injury, degenerative disease, congenital abnormalities, and/or the aging process.
La présente invention concerne des procédés et des compositions convenant au traitement, l'augmentation et/ou la réparation de tissus mous et/ou durs d'animaux, et en particulier de vertébrés tels que les humains. L'invention concerne plus particulièrement des compositions d'hydrogels convenant à l'élaboration de médicaments pour la guérison des blessures, la réparation des cartilages et ménisques, l'augmentation dermale, et la fusion osseuse, ainsi que des procédés pour le traitement des lésions des disques intervertébraux. Dans des modes de réalisation particuliers, l'invention concerne des compositions convenant à la restauration de la fonction hydrodynamique, l'accroissement de la hauteur des disques intervertébraux, et à l'amélioration de la prolifération et la survie des chondrocytes et autres cellules des disques intervertébraux qui ont été malmenés par les blessures, les maladies dégénératives, les anomalies congénitales, et/ou le vieillissement.
Chandrashekhar Pathak
Moehlenbruck Jeff
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Zimmer Orthobiologics Inc.
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