Hydrogel compositions for the controlled release...

Details Hydrogel compositions for the controlled release... Hydrogel compositions for the controlled release...

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61K 9/06 (2006.01) A61K 9/10 (2006.01) A61K 38/19 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2341410

Compositions and methods are disclosed for the controlled release delivery of polypeptide growth factors. The compositions of the invention are hydrogels which comprise: a polypeptide growth factor having at least one region of positive charge; a physiologically acceptable water-miscible anionic polymer, a physiologically acceptable non- ionic polymeric viscosity controlling agent; and water.

La présente invention concerne des compositions et des procédés d'apport par libération régulé de facteurs de croissance polypeptidiques. Les compositions de cette invention sont des hydrogels qui renferment: un facteur de croissance polypeptidique présentant au moins un site de charge positive; un polymère anionique miscible avec l'eau acceptable sur le plan physiologique; un agent polymère non-ionique régulateur de la viscosité acceptable sur le plan physiologique; et enfin, de l'eau.

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