Hydrogel films and methods of making and using therefor

Details Hydrogel films and methods of making and using therefor Hydrogel films and methods of making and using therefor

C - Chemistry, Metallurgy

08

G

C08G 63/48 (2006.01) A61K 9/14 (2006.01) A61K 47/36 (2006.01) C08B 11/20 (2006.01) C08B 15/00 (2006.01) C08B 37/00 (2006.01) C08B 37/08 (2006.01) C08G 63/91 (2006.01) C08G 65/00 (2006.01) C08G 65/336 (2006.01)

Patent

CA 2416698

The present invention provides improved hydrogel films useful for therapeutic treatments. The invention also provides materials and methods for modification and polymerization of polysaccharides into hydrogel films, which swell after exposure to a neutral aqueous solution. The methods may include modification of a polysaccharide having at least one carboxylic acid group into a polysaccharide dihydrazide derivative, which is then crosslinked with a polyaldehyde to create a hydrogel film. The invention also relates pharmaceutical compositions composed of a pharmaceutically-acceptable compound and a hydrogel film of the invention. The invention also relates to using the hydrogel films and pharmaceutical compositions of the invention.

Cette invention se rapporte à des films d'hydrogel améliorés utiles dans des traitements thérapeutiques. Cette invention concerne également des matières et des procédés servant à modifier et à polymériser des polysaccharides en films d'hydrogel qui gonflent après exposition à une solution aqueuse neutre. Ces procédés peuvent consister à modifier un polysaccharide ayant au moins un groupe acide carboxylique en un dérivé dihydrazide de polysaccharide, lequel est ensuite réticulé avec un polyaldéhyde pour créer un film d'hydrogel. Cette invention concerne également des compositions pharmaceutiques constituées par un composé pharmaceutiquement acceptable et par un film d'hydrogel décrit ci-dessus. Cette invention concerne en outre l'utilisation de ces films d'hydrogels et de ces compositions pharmaceutiques.

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