Hydrogel materials

A - Human Necessities – 61 – K

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Details

A61K 47/42 (2006.01) A61L 24/10 (2006.01) C08G 65/32 (2006.01)

Patent

CA 2686920

The present invention relates to biocompatible crosslinked biomate rials made from polycondensation polymerization reactions involving polynucleophilic- polyelectrophilic precursors that address the limitations of steric hindrance, viscosity, and diffusion currently reducing gelation rates and curing thoroughness of the biomaterials. A cross-linking scheme is utilized in the invention that permits rapid gelation and thorough curing of the biomaterial. The biomaterial is made by polycondensation polymerization of polynucleophilic-polyelectrophilic precursors to form a water-soluble polymer crosslinked with a water-soluble crosslinker having at most one core cyclic structure.

La présente invention concerne des biomatériaux réticulés biocompatibles fabriqués par des réactions de polymérisation par polycondensation mettant en jeu des précurseurs polynucléophiles-polyélectrophiles qui permettent de résoudre les problèmes d'empêchement stérique, de viscosité et de diffusion qui abaissent actuellement les vitesses de gélification et le caractère complet du durcissement des biomatériaux. L'invention utilise un schéma de réticulation qui permet la gélification rapide et un durcissement complet du biomatériau. Le biomatériau est fabriqué par polymérisation par polycondensation de précurseurs polynucléophiles-polyélectrophiles pour former un polymère soluble dans l'eau réticulé avec un agent de réticulation soluble dans l'eau ayant au maximum une structure cyclique de base.

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