Hydrogel wound dressing and biomaterials formed in situ and...

A - Human Necessities – 61 – L

Patent

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Details

A61L 15/00 (2006.01) A61L 15/14 (2006.01) A61L 27/52 (2006.01) A61L 27/54 (2006.01)

Patent

CA 2666315

The present invention relates to a method of forming shape-retentive and shape-conforming aggregate wound dressings and biomaterials composed of gel nanoparticles and wound or bodily fluid in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a dry powder of gel nanoparticles to a wound site in which the nanoparticles absorb some of the blood or wound exudate and coalesce in situ into the claimed shape-retentive aggregate dressing. The method also comprises introducing the dry nanoparticle powder in or on a wet bodily tissue in vivo to form the claimed shape-retentive biomaterial. In addition, the method also comprises incorporating biomedical agents to produce medicated aggregate dressings or biomaterials for a variety of medical applications. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel nanoparticles.

La présente invention concerne un procédé pour former des pansements d'agrégats à rétention de forme et à conformation de forme et des biomatériaux composés de nanoparticules de gel et de liquides organiques dans lesquels les agrégats sont maintenus ensemble par des forces physiques de liaison non covalente telles que, sans limitation, des interactions hydrophobes-hydrophiles et des liaisons hydrogène. Le procédé comprend l'introduction d'une poudre sèche de nanoparticules de gel au site de la blessure où les particules absorbent une partie du sang ou de l'exsudat de la blessure et coalescent in situ en un pansement d'agrégats à rétention de forme tel que revendiqué par les présentes. Le procédé comprend également l'introduction de la poudre de nanoparticules sèche dans ou sur un tissu cellulaire humide in vivo pour former le biomatériau à rétention de forme tel que revendiqué par les présentes. En outre, le procédé comporte également l'incorporation d'agents biomédicaux pour produire des pansements d'agrégats médicamenteux ou des biomatériaux pour une variété d'applications médicales. L'invention concerne également des utilisations du procédé pour former les agrégats à rétention de forme de nanoparticules de gel.

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