Hydrogels derived from chitosan and poly(ethylene glycol) or...

Details Hydrogels derived from chitosan and poly(ethylene glycol) or... Hydrogels derived from chitosan and poly(ethylene glycol) or...

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2376714

The invention provides a polymeric structure comprising a multifunctional poly(alkylene oxide), such as a poly(ethylene glycol) derivative, covalently cross-linked to a polymer selected from the group consisting of chitosan and conjugates of chitosan and a monofunctional poly(alkylene oxide), such as methoxy poly(ethylene glycol). In aqueous media, the polymeric structure forms a hydrogel that is useful as a drug delivery device, a surgical sealant, or as a delivery system for a medical imaging agent.

L'invention concerne une structure polymère renfermant un poly(alkylène oxyde) multifonctionnel, tel qu'un dérivé de poly(éthylène glycol), réticulé par covalence à un polymère sélectionné dans le groupe constitué par le chitosane et des conjugués de chitosane et un poly(alkylène oxyde) monofonctionnel, tel que le méthoxy poly(éthylène glycol). Dans un milieu aqueux, la structure polymère forme un hydrogel utile comme dispositif d'apport médicamenteux, comme agent de scellement chirurgical, ou comme système de distribution d'un agent d'imagerie médicale.

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