Hydrogels of hyaluronic acid and alpha,...

Details Hydrogels of hyaluronic acid and alpha,... Hydrogels of hyaluronic acid and alpha,...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 47/36 (2006.01)

Patent

CA 2572127

Compositions and products based on the chemical crosslinking of hyaluronic acid with a polyfunctional polymer having a protein-like structure, bearing hydrazido pendent groups along the polymeric chain. The polymer is preferably, alpha-beta--polyaspartylhydrazide, a biocompatible macromolecule. The materials obtained after crosslinking, specifically hydrogels, undergo a reduced chemical and enzymatic degradation, unlike the starting hyaluronic acid, and they can be used to prepare systems for applications in the biomedical and pharmaceutical field.

L'invention concerne des compositions et des produits basés sur des réticulations chimiques d'acide hyaluronique avec un polymère polyfonctionnel possédant une structure de type protéine, supportant des groupes hydrazido pendant sur la chaîne polymère. Le polymère consiste, de préférence, en du polyaspartyl-hydrazide alpha-bêta, une macromolécule bicompatible. Les matériaux obtenus après réticulation, notamment les hydrogels, sont soumis à une dégradation enzymatique et chimique réduite, par opposition à l'acide hyaluronique de départ, et peuvent être utilisés afin de préparer des systèmes pour des applications dans les domaines pharmaceutique et biomédical.

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