Hydrogels that undergo volumetric expansion in response to...

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A61L 27/14 (2006.01) A61F 2/00 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/70 (2006.01) A61K 31/74 (2006.01) A61K 47/48 (2006.01) A61K 49/04 (2006.01) A61K 51/00 (2006.01) A61L 27/50 (2006.01) A61L 27/52 (2006.01)

Patent

CA 2439925

Hydrogels that expand volumetrically in response to a change in their environment (e.g., a change in pH or temperature) and their methods of manufacture and use. Generally, the hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion(s) of which are sensitive to environmental changes (e.g., changes in pH or temperature), b) a crosslinker and c) a polymerization initiator. If desired, a porosigen may be incorporated into the liquid reaction mixture to create pores. After the hydrogel is formed, the porosigen is removed to create pores in the hydrogel. The hydrogel may also be treated to cause it to assume a non-expanded volume in which it remains until a change in its environment causes it to expand. These hydrogels may be prepared in many forms including pellets, filaments, and particles. Biomedical uses of these hydrogels include applications wherein the hydrogel is implanted in the body of a patient and an environmental condition at the implantation site causes the hydrogel to expand it situ.

L'invention concerne des hydrogels qui se dilatent volumétriquement en réponse à un changement de leur environnement (p. ex. un changement de pH ou de température), ainsi que leurs procédés de fabrication et d'utilisation. Les hydrogels se préparent généralement en formant un mélange de réaction liquide qui contient a) des monomères et/ou des polymères, certaines parties desquels au moins sont sensibles à des changements d'environnement (p. ex. des changements de pH ou de température), b) un agent de réticulation et c) un initiateur de polymérisation. On peut, si on le souhaite, incorporer un agent porogène dans le mélange de réaction liquide afin de créer des pores. Après la formation de l'hydrogel, le porosigène est retiré pour créer les pores dans ledit hydrogel. Ce dernier peut également être traité pour qu'il adopte un volume non dilaté qu'il garde jusqu'à ce qu'un changement d'environnement entraîne une dilatation du volume. Ces hydrogels peuvent être préparés sous de nombreuses formes dont des granules, des filaments et des particules. Parmi les utilisations biomédicales de ces hydrogels, figurent des applications dans lesquelles l'hydrogel est implanté dans le corps d'un patient et une condition environnementale au site d'implantation entraîne l'hydrogel à se dilater in situ.

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