Hydrogels with increased organic solvent soluble active...

A - Human Necessities – 61 – K

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167/166, 71/47,

A61K 47/08 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01)

Patent

CA 1296459

Hydrogels with increased organic solvent soluble active agent loading capacity, their preparation and the use thereof Abstract of the disclosure An organic solvent soluble active agent containing water-insoluble hydrophilic hydrogel comprising a copolymer of (A) a water-soluble monoolefinic monomer or a mixture thereof optionally containing up to 50 % thereof of one or more water-insoluble monoolefinic monomers and (B) a terminally diolefinic hydrophobic macromer containing polypropylene oxide or polytetramethylene oxide units prepared in the presence of an effective macromer expanding amount of a macromer soluble compound of the formula R'?R"-O?nR''' where R', R", R''' and n are as defined in the claims, hydrogels useful in the loading of such active agents, their preparation, and use are disclosed.

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