A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4035 (2006.01)
Patent
CA 2611550
The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
La présente invention concerne certains composés hydro-iso-indoliques utiles en tant qu~antagonistes des récepteurs de la neurokinine-1 (NK-1) et inhibiteurs de la tachykinine, tout particulièrement de la substance P. L~invention concerne également les formulations pharmaceutiques contenant ces composés en tant qu~ingrédients actifs, ainsi que l~utilisation de ces composés et de leurs formulations pour le traitement de certains troubles, tels que les vomissements, l~incontinence urinaire, la dépression et l~anxiété.
Devita Robert J.
Jiang Jinlong
Kumar Sanjeev
Mills Sander G.
Tschirret-Guth Richard A.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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