C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/44 (2006.01) A61K 31/4035 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2554550
The present invention is directed to certain hydroisoindoline compounds of formula I which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
L'invention concerne certains composés d'hydroisoindoline de formule I utiles comme antagonistes des récepteurs de la neurokinine-1 (NK-1) et des inhibiteurs de la tachykinine et, plus précisément, de la substance P. L'invention concerne également des formulations pharmaceutiques renfermant ces composés comme principes actifs et l'utilisation de ces composés et des formulations de ceux-ci dans le traitement de certains troubles, notamment les vomissements, l'incontinence urinaire, la dépression et l'anxiété.
Bunda Jaime Lynn
Devita Robert J.
Jiang Jinlong
Mills Sander G.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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