Hydroisoindolines and hydroisoquinolines as psychotropic

Details Hydroisoindolines and hydroisoquinolines as psychotropic Hydroisoindolines and hydroisoquinolines as psychotropic

C - Chemistry, Metallurgy

07

D

C07D 209/44 (2006.01) A61K 31/40 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 209/16 (2006.01) C07D 209/48 (2006.01) C07D 217/04 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2130123

2130123 9316047 PCTABS00025 A compound having formula (I) wherein: n = 1 or 2; the A ring may contain one double bond; R1 is selected from the group including: C1-C8 alkyl substituted with 1 or more R4, C3-C8 cycloalkyl, and C4-C10 cycloalkyl-alkyl; R4 may be aryl optionally substituted or may be a heterocyclic ring system. The compounds are useful in the treatment of physiological or drug induced psychosis or dyskinesia in a mammal. These novel compounds are selective sigma receptor antagonists and have a low potential for movement disorder side effects associated with typical antipsychotic agents.

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