Hydroisoquinoline derivatives

Details Hydroisoquinoline derivatives Hydroisoquinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 491/04 (2006.01) C07D 491/044 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2112744

2112744 9301186 PCTABS00019 Compounds of formula (I) in which, R is linear or branched alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, aryl, aralkyl or furan-2-yl alkyl; R1 and R2, which may be the same or different, are each hydrogen, hydroxy, alkoxy, or halogen; R3 is hydrogen, hydroxy or alkoxy; "Het" is optionally substituted single or fused heteroxyclic ring, containing from 5 to 10 ring atoms and comprising up to four heteratoms in the or each ring, selected from oxygen, nitrogen and sulphur; R4 and R5, which may be the same or different, are each hydrogen alkyl, halogen, nitro, CF, cyano, alkoxy carbonyl, NH, alkylcarbonylamino, hydroxy, alkoxy, or benzyl, are selective delta receptor agonists and are useful in the treatment of pain.

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