Hydrolysis and photocleavage of nucleic acid using a metal...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/00 (2006.01) A61K 31/40 (2006.01) A61K 31/70 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) C12N 13/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2221128

A particular class of metal complexes, specifically certain texaphyrin metal complexes, which both hydrolyze and photocleave ribonucleic acid, and which also both hydrolyze ribonucleic acid and photocleave deoxyribonucleic acid, is provided. The texaphyrin metal complex for each set of reactions has catalytic activity for phosphate ester hydrolysis and is photosensitive. A complex having the advantage of multiple activities can result in lower treatment dosages and lower treatment costs.

L'invention concerne une classe particulière de complexes métalliques, spécifiquement des complexes métalliques de texaphyrine, qui ont une action à la fois d'hydrolyse et de photoclivage sur l'acide ribonucléique, et qui ont également une action d'hydrolyse sur l'acide ribonucléique et de photoclivage sur l'acide désoxyribonucléique. Le complexe métallique de texaphyrine pour chaque groupe de réactions présente une activité catalytique pour l'hydrolyse d'ester de phosphate et est photosensible. Un complexe présentant l'avantage d'actions multiples peut permettre des dosages thérapeutiques inférieurs et conduire à des coûts de traitement réduits.

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