C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/34 (2006.01) C07D 307/00 (2006.01) C07D 311/10 (2006.01) C07D 493/10 (2006.01) C12Q 1/00 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2388904
Compounds of the invention have the structure D-L-A*, where L is a linking moiety that maintains D and A in a configuration compatible with FRET, D is a fluorescent donor moiety capable of causing an acceptor moiety to fluoresce by FRET, and A* is a fluorescent acceptor moiety capable of accepting energy from the donor moiety by FRET and fluorescing only after cleavage of one or more labile groups to provide acceptor A. These compounds are useful as fluorescent substrates for detection of enzymes in vivo.
Cette invention concerne des composés de structure D-L-A*, dans laquelle L est une fraction de liaison maintenant D et A dans une configuration compatible avec FRET (transfert par résonance d'énergie de fluorescence), D est une fraction donneur fluorescente capable de déclencher par FRET une fluorescence dans une fraction receveur, et A* est une fraction receveur fluorescente pouvant recevoir de l'énergie la fraction donneur par FRET et de devenir fluorescente uniquement après clivage d'un ou plusieurs groupes instables pour donner le receveur A. Ces composés sont utiles comme substrats fluorescents pour la détection d'enzymes in vivo.
Jarnigan Kurt
Lee Ving J.
Leger Roger
Morgans David
Gowling Lafleur Henderson Llp
Iconix Pharmaceuticals Inc.
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