Hydrolyzed cellulose granulations for pharmaceuticals

Details Hydrolyzed cellulose granulations for pharmaceuticals Hydrolyzed cellulose granulations for pharmaceuticals

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 31/135 (2006.01) A61K 31/19 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2252394

The present invention provides a method for preparing a spray-dried compressible granular formulation for preparing pharmaceutical tablets in which hydrolyzed cellulose is used as a granulation aid, the resulting granulations, and pharmaceutical tablets compressed from such granules. In these formulations there is employed from 1 to 97 % by weight pharmaceutical active, from about 3 to 99 % by weight hydrolyzed cellulose, based on the dry weight of the granulation, and optionally conventional granulation and/or tableting additives such as surfactants, disintegrants and antiadherents/flow aids.

L'invention concerne un procédé permettant de préparer une formulation en granulés compressibles, séchés par pulvérisation, pour préparer des comprimés pharmaceutiques dans lesquels la cellulose hydrolysée est utilisée comme auxiliaire de granulation, ainsi que les granulés obtenus et les comprimés pharmaceutiques fabriqués à partir de desdits granulés. Ces formulations contiennent 1 à 97 % en poids de substance pharmaceutique active, 3 à 99 % en poids de cellulose hydrolysée, sur la base du poids sec des granulés, et éventuellement des additifs conventionnels de granulation et/ou de fabrication de comprimés, tels qu'agents tensioactifs, désintégrants et auxiliaires anti-adhérents/d'écoulement.

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