Hydromorphinone and hydrocodeinone compositions and methods...

Details Hydromorphinone and hydrocodeinone compositions and methods... Hydromorphinone and hydrocodeinone compositions and methods...

C - Chemistry, Metallurgy

07

D

C07D 489/02 (2006.01)

Patent

CA 2674424

A method for the preparation of a ketone from a narcotic alkaloid having an allyl alcohol moiety is disclosed. The method includes mixing the narcotic alkaloid with an acid in the presence of a catalyst wherein the method is carried out in the substantial absence of hydrogen gas. The method is useful for preparing hydromorphone and hydrocodone compositions having novel impurity profiles. Compositions comprising hydromorphone and hydrocodone are also disclosed.

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