A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 43/04 (2006.01) A61K 31/715 (2006.01) C07H 5/04 (2006.01) C07H 5/06 (2006.01) C08B 37/00 (2006.01)
Patent
CA 2603245
The present invention provides a hydrophilic inclusion complex consisting essentially of nanosized particles of an active compound in amorphous form and an amphiphilic polymer which wraps the active compound such that non-valent bonds are formed between the active compound and the amphiphilic polymer. The invention further provides hydrophilic dispersions comprising said inclusion complexes, particularly of pharmaceutical drugs, and stable pharmaceutical compositions comprising said dispersions of the pharmaceutical drugs in amorphous form.
La présente invention concerne un complexe d'inclusion hydrophile renfermant essentiellement des nanoparticules d'un composé actif sous une forme amorphe et un polymère amphiphile qui enrobe le composé actif, de telle manière que des liaisons non valentes sont formées entre le composé actif et le polymère amphiphile. Ladite invention a, également, trait à des dispersions hydrophiles contenant lesdits complexes d'inclusion, notamment, des médicaments pharmaceutiques et des compositions pharmaceutiques stables renfermant lesdites dispersions des médicaments pharmaceutiques sous une forme amorphe.
Goldshtein Rina
Jaffe Irene
Tulbovitz Boris
Borden Ladner Gervais Llp
Solubest Ltd.
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