C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 63/676 (2006.01) A61F 2/28 (2006.01) A61F 2/46 (2006.01) C08G 63/78 (2006.01) C08J 3/24 (2006.01) C08L 67/06 (2006.01)
Patent
CA 2606396
Improved methods for preparing polyethylene glycol fumarate) are disclosed. Methods for chemically crosslinking or photocross-linking hydrophilic polyethylene glycol fumarate) with hydrophobic polymers such as poly(propylene fumarate) (PPF) and poly(caprolact5one fumarate) (PCLF) to form various hydrogels (Fig. 1) with controllable hydrophilicity are also disclosed. The hydrogels are useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction. An injectable material including the hydrogels may be useful in controlled drug release.
L'invention concerne des procédés améliorés de préparation de poly(éthylène glycol fumarate). L'invention concerne également des procédés de réticulation ou de photoréticulation chimique de poly(éthylène glycol fumarate) hydrophile avec des polymères hydrophobes, tels que le poly(propylène fumarate) (PPF) et le poly(caprolactone fumarate) (PCLF), destinés à former divers hydrogels (figure 1) présentant une hydrophilicité régulable. Ces hydrogels sont utiles dans la fabrication de structures de durcissement injectables et in situ destinées à être utilisées dans la reconstruction du squelette. Un matériau injectable contenant ces hydrogels peut être utile dans la libération contrôlée de médicament.
Lu Lichun
Wang Shanfeng
Yaszemski Michael J.
Goudreau Gage Dubuc
Mayo Foundation For Medical Education And Research
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