Hydrophilic microparticles and methods to prepare same

Details Hydrophilic microparticles and methods to prepare same Hydrophilic microparticles and methods to prepare same

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 9/16 (2006.01) A61K 9/51 (2006.01) A61K 31/415 (2006.01) A61K 31/495 (2006.01) B01J 13/00 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2267973

The present invention comprises a material and a method of its preparation. The material may be described as hydrophilic microparticles, comprising a cluster of organic substance with a layer of polyelectrolyte on its surface. The present invention establishes an improved method for preparing aqueous colloidal dispersions of water-insoluble organic substances using polyionic hydrophilic polymers by which the stability of the suspension is maintained after removal of the stabilizing and/or solubilizing medium of the drug. This improved method can be utilized to formulate a variety of water-insoluble organic substances.

Cette invention concerne une matière et un procédé permettant de la préparer. La matière peut se présenter sous forme de microparticules hydrophiles comprenant un amas de substance organique comportant sur sa surface une couche de polyélectrolyte. Le procédé amélioré de cette invention permet de préparer des dispersions colloïdales aqueuses de substances organiques insolubles dans l'eau à l'aide de polymères hydrophiles polyioniques qui assurent le maintien de la stabilité de la suspension après l'élimination du milieu de stabilisation et/ou de solubilisation du médicament. Ce procédé amélioré peut être utilisé pour formuler une grande variété de substances organiques insolubles dans l'eau.

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