Hydrophilic, swellable coatings for biosensors

Details Hydrophilic, swellable coatings for biosensors Hydrophilic, swellable coatings for biosensors

A - Human Necessities

61

L

A61L 27/34 (2006.01) A61B 5/00 (2006.01) A61L 27/00 (2006.01) A61L 27/52 (2006.01) A61N 1/05 (2006.01) C09D 201/06 (2006.01) C12Q 1/00 (2006.01) G01N 27/327 (2006.01) G01N 27/416 (2006.01)

Patent

CA 2238648

Methods for reducing the electrode impedance of implantable biosensors by coating the surface of the biosensor with a uniform hydrogel which allows unimpeded water movement around the sensor are provided. The surface coatings are compositions which are biocompatible and are capable of water uptake of at least 120 % of their weight, more preferably at least 200 % of their weight. Upon the uptake of water, the hydrogels used in the present invention will also swell and provide a layer of water around the electrodes to which the hydrogels are attached. The hydrogels can be prepared from (a) a diisocyanate, (b) a hydrophilic polymer which is a hydrophilic diol, a hydrophilic diamine, or a combination thereof, and optionally, (c) a chain extender.

Cette invention concerne des procédés visant à réduire l'impédance des électrodes de biocapteurs implantables et consistant à recouvrir la surface du capteur avec un hydrogel uniforme qui permet un déplacement sans entrave de l'eau autour du capteur. Ces revêtements de surface sont des compositions biocompatibles susceptibles d'absorber au moins 120 % de leur poids en eau, de préférence au moins 200 % de leur poids. Lorsqu'ils absorbent l'eau, les hydrogels de la présente invention gonflent et forment une couche d'eau autour des électrodes auxquelles ils sont attachés. On peut préparer ces hydrogels à partir (a) d'un diisocyanate, (b) d'un polymère hydrophile qui est un diol hydrophile, d'une diamine hydrophile ou d'une combinaison de ces deux composés, et éventuellement (c) d'un allongeur de chaîne.

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