Hydrophobic attachment site for adhesion peptides

Details Hydrophobic attachment site for adhesion peptides Hydrophobic attachment site for adhesion peptides

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 14/78 (2006.01) C07K 17/02 (2006.01) C07K 17/06 (2006.01) C07K 17/14 (2006.01)

Patent

CA 2046631

2046631 9011297 PCTABS00002 The invention provides a method of attaching peptides containing a RGD adhesion peptides, to a solid surface through a hydrophobic domain, and peptides so attached. The hydrophobic domain can contain either hydrophobic amino acids, such as leucine, valine, isoleucine or phenylalanine, or fatty acids, such as, for example, myristic acid, palmitic acid, arachidic acid or other fatty acids. Additionally, spacers, such as amino acids, between the hydrophobic domain and the biologically active domain can improve the presentation of the biologically active site. Specific peptides of the invention include GRGDSPASSKG4SRL6RNH2; GRGDSPASSKS3RL6RNH2; AND GRGDSPASSKSSKRL6RNH2. Coupled to a solid surface, such peptides can be used to detect the presence of a ligand complementary to the biologically active site.

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