Hydrophobic carbomer complex compositions

Details Hydrophobic carbomer complex compositions Hydrophobic carbomer complex compositions

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/56 (2006.01)

Patent

CA 2251849

Hydrophilic carbomer complexes, such as bismuth or nicotine carbomer, are rendered hydrophobic at neutral to acid pH by milling to pass a 150 µm sieve screen and then impregnating with a water-insoluble anionic polymer. Preferred anionic polymers are partly methyl esterified methacrylic acid polymers.

On rend hydrophobes des complexes carbomères (polymères de carboxypolyméthylène) hydrophiles, tels qu'un carbomère de bismuth ou de nicotine, afin de changer leur pH neutre en un pH acide, en les broyant afin qu'il puissent passer au travers d'un tamis de 150 µm, et en les imprégnant ensuite d'un polymère anionique insoluble dans l'eau. Les polymères anioniques que l'on préfère sont des polymères d'acide méthacrylique partiellement estérifiés par méthyle.

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