Hydrophobic cis-platinum complexes efficiently incorporated...

Details Hydrophobic cis-platinum complexes efficiently incorporated... Hydrophobic cis-platinum complexes efficiently incorporated...

C - Chemistry, Metallurgy

07

F

260/429.4, 260/4

C07F 15/00 (2006.01) A61K 9/127 (2006.01) A61K 31/685 (2006.01)

Patent

CA 1312616

ABSTRACT The present invention involves the synthesis and use of new platinum compounds. These new platinum compounds are easy to encapsulate in liposomes at high efficiencies. They are further characterized as platinum (II) four coordinate complex having the formula: Image wherein R1 and R2 are carboxylato monoanions bearing a hydrophobic radical function or a single carboxylato dianion bearing a hydrophobic radical function and R3 is a vicinal diaminoalkane or vicinal diaminocycloalkane. The complex is substantially soluble in methanol or chloroform and substantially insoluble in water. Said complex may be incorporated into phospholipid liposomes. Such platinum complexes encapsulated in phospholipid liposomes are useful for chemotherapy of platinum complex-sensitive tumors.

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