Hydrophobic polymeric microparticles

Details Hydrophobic polymeric microparticles Hydrophobic polymeric microparticles

C - Chemistry, Metallurgy

12

N

C12N 11/08 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2172040

A method for the preparation of microparticles, and the product thereof, that include dispersing a substantially water insoluble non-ionic or ionic polymer in an aqueous solution in which the substance to be delivered is also dissolved, dispersed or suspended, and then coagulating the polymer together with the substance by impact forces to form a microparticle. In an alternative embodiment, the microparticle is formed by coagulation of an aqueous polymeric dispersion through the use of electrolytes, pH changes, organic solvents in low concentrations (the minimal amount necessary to break up the dispersion), or temperatures changes to form polymer matrices encapsulating biological materials.

Procédé de préparation de microparticules et produit résultant consistant à disperser un polymère ionique ou non ionique non hydrosoluble dans une solution aqueuse où le produit à administrer se trouve sous forme de solution, de dispersion ou de suspension, puis à coaguler par des chocs le polymère avec ledit produit de façon à former des microparticules. Dans une autre réalisation, les microparticules sont formées par coagulation d'une dispersion polymére aqueuse à l'aide d'électrolytes, de variations de pH, de solvants organiques à faible concentration (le minimum nécessaire pour désagréger la dispersion) ou de variations de température. On obtient ainsi des matrices de polymères renfermant les matériaux biologiques.

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