Hydrophobic substrate able to release a chemical substance

C - Chemistry – Metallurgy – 08 – L

Patent

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167/166, 400/300

C08L 51/00 (2006.01) A61F 6/14 (2006.01) A61K 9/00 (2006.01) A61M 31/00 (2006.01) C08J 7/18 (2006.01)

Patent

CA 1171580

ABSTRACT Hydrophobic substrate which can release at least one chemical substance, wherein it comprises a hydrophobic polymer matrix in which are homogeneously distributed inclusions of polymerized compounds of a different type to the said hydrophobic polymer and inclusions of the said substance, the polymerized compound inclusions forming in the said matrix a stable and continuous system in contact with the inclusions of the said substance. Process for the preparation of a hydropic substrate able to release a chemical substance, wherein it comprises forming inclusions of polymerized compounds in a hydrophobic polymer powder by grafting onto the latter a monomer of a different type to the said hydrophobic polymer, homogeneously mixing the grafted powder obtained in this way with a powder of the said substance and bringing the mixture into the form of a substrate by hot shaping it. The hydrophobic substrate is particularly useful in dis- pensing under controlled conditions solid chemicals such as therapeutic agents when positioned in a body cavity.

334446

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