Hydroxamate sulfonamides as cd23 shedding inhibitors

Details Hydroxamate sulfonamides as cd23 shedding inhibitors Hydroxamate sulfonamides as cd23 shedding inhibitors

C - Chemistry, Metallurgy

07

D

C07D 211/96 (2006.01) A61K 31/451 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2528316

A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.

L'invention concerne une classe de piperidines et de dérivés hétérocycliques associés, substitués sur le carbone par un aryle substitué ou une fraction hétéroaryle et substitués sur l'azote par un groupe éthylsulfonyle qui est lui-même substitué sur la position 2 par une fraction d'acide hydroxamique et également par une gamme de substituants de remplacement. Les composés selon l'invention sont de puissants inhibiteurs de l'élimination de CD23 et sont utilisés dans le traitement et/ou la prévention de maladies allergiques, inflammatoires et néoplastiques.

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