A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/609 (2006.01) A61K 8/42 (2006.01) A61K 8/49 (2006.01) A61K 31/16 (2006.01) A61K 31/164 (2006.01) A61K 31/19 (2006.01) A61K 31/44 (2006.01) A61K 31/4409 (2006.01) A61K 31/455 (2006.01) A61P 17/00 (2006.01) A61Q 19/02 (2006.01)
Patent
CA 2471953
Methods, compounds, and formulations are provided to reduce pigmentation in mammalian skin, comprising hydroxamic acid and its derivatives, and especially benzohydroxamic acid and its derivatives. The compounds preferably inhibit pigment synthesis in melanocytes through inhibition of melanocyte tyrosinase. The methods can be used for lightening skin, and for treating uneven skin complexions, which result from hyperpigmentation-related medical conditions such as melasma, age spots, freckles, ochronosis, and lentigo. The compounds can be used medically or cosmetically, and preferably as topical formulations.
L'invention concerne des procédés, des composés et des formulations permettant de réduire la pigmentation de la peau chez un mammifère, renfermant un acide hydroxamique et ses dérivés, et plus spécifiquement un acide benzohydroxamique et ses dérivés. Les composés inhibent de préférence la synthèse de pigment dans les mélanocytes par le biais de l'inhibition de la mélanocyte tyrosinase. Les procédés peuvent être utilisés pour l'éclaircissement de la peau et pour traiter un teint irrégulier, dû à des états pathologiques associés à l'hyperpigmentation, notamment le mélasme, les taches cutanées séniles, les taches de rousseur, l'ochronose et le lentigo. Les composés ont une application médicale ou cosmétique, et servent de préférence de formulations topiques.
Cheng Lin
Dooley Thomas P.
Bull Housser & Tupper Llp
Mediquest Therapeutics Inc.
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