Hydroxamic acid based collagenase inhibitors

Details Hydroxamic acid based collagenase inhibitors Hydroxamic acid based collagenase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/185 (2006.01) A61K 31/33 (2006.01) A61K 31/38 (2006.01) C07C 237/22 (2006.01) C07C 311/46 (2006.01) C07C 317/50 (2006.01) C07C 323/60 (2006.01) C07D 333/34 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2242913

Compounds of formula (I) wherein R and R3 are each independently hydrogen, alkyl, alkenyl, alkynyl or aryl; R1 is arylmethyl; and R2 is alkyl, alkenyl, aryl, cycloalkyl or cycloalkenyl, and pharmaceutically acceptable derivatives thereof, are useful in the treatment and prophylaxis of disorders in which the overproduction of sCD23 is implicated.

On décrit des composés de la formule (I) ainsi que des dérivés de ceux-ci, acceptables sur le plan pharmacologique. Dans cette formule, R et R?3¿ représentent chacun indépendamment hydrogène, alkyle, alcényle, alcynyle ou aryle, R?1¿ représente arylméthyle et R?2¿ représente alkyle, alcényle, aryle, cycloalkyle ou cycloalcényle. Ces composés sont utiles dans le traitement et la prophylaxie de troubles dans lesquels une surproduction de CD23 soluble est impliquée.

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