C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 259/06 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) A61K 38/05 (2006.01) C07C 279/14 (2006.01) C07C 309/18 (2006.01) C07C 317/28 (2006.01) C07C 323/41 (2006.01) C07D 209/48 (2006.01) C07D 211/76 (2006.01) C07D 223/10 (2006.01) C07D 233/64 (2006.01) C07D 239/22 (2006.01) C07D 243/08 (2006.01) C07D 245/02 (2006.01) C07D 265/10 (2006.01) C07D 295/185 (2006.01) C07D 307/54 (2006.01) C07D 307/81 (2006.01) C07D 309/30 (2006.01) C07D 313/00 (2006.01) C07D 333
Patent
CA 2208679
The invention provides hydroxamic acid-containing compounds which are useful as inhibitors of matrix metalloproteases and which are effective in treating conditions associated with excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to formula (I), wherein: (A) R1, R2, R3, R4 and R5 are independently selected from various substituents; and (B) where R3 and R4 or R4 and R5 may together comprise a cyclic moiety; or a pharmaceutically-acceptable salt, biohydrolyzable amide or biohydrolyzable ester thereof. In other aspects, the invention is directed to pharmaceutical compositions containing the compounds of formula (I), and to methods of treating diseases characterized by matrix metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
Des composés contenant l'acide hydroxamique sont utiles comme inhibiteurs des métalloprotéases matricielles et efficaces pour traiter des maladies associées à une activité excessive de ces enzymes. En particulier, l'invention concerne un composé ayant une structure conforme à la formule (I), dans laquelle (A) R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ sont sélectionnés indépendamment les uns des autres parmi différents substituants; et (B) R?3¿ et R?4¿ ou R?4¿ et R?5¿ peuvent comprendre ensemble une fraction cyclique ou un sel, amide ou ester biohydrolysables pharmaceutiquement acceptables de ces composés. D'autres aspects de l'invention concernent des compositions pharmaceutiques qui contiennent les composés ayant la formule (I) et des procédés de traitement de maladies caractérisées par une activité des métalloprotéases matricielles au moyen de ces composés ou des compositions pharmaceutiques qui les contiennent.
Kirby Eades Gale Baker
The Procter & Gamble Company
LandOfFree
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