Hydroxamic acid derivative

Details Hydroxamic acid derivative Hydroxamic acid derivative

C - Chemistry, Metallurgy

07

C

C07C 323/47 (2006.01) A61K 31/16 (2006.01) A61K 31/265 (2006.01) C07C 237/22 (2006.01) C07C 259/06 (2006.01) C07C 323/57 (2006.01) C07C 323/60 (2006.01) C07C 327/20 (2006.01) C07C 327/30 (2006.01) C07C 327/32 (2006.01) C07C 327/34 (2006.01)

Patent

CA 2122046

ABSTRACT Image A compound represented by general formula (I), a pharmaceutical composition containing same, a process for the production thereof, and an intermediate therefor. In formula (I) R1 represents lower alkyl which may be substituted by a substituent selected from the group consisting of mercapto, lower alkylthio, arylthio and lower acylthio; R2, R3 and R4 may be the same or different from one another and each represents lower alkyl; X represents oxygen or sulfur; and Y represents a single bond or lower alkylene. The compound (I) has a matrix metalloprotease inhibitory activity and is useful for preventing and treating diseases caused by the progress of connective tissue breakage. - 54 -

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