Hydroxamic acid derivatives

Details Hydroxamic acid derivatives Hydroxamic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 295/18 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/535 (2006.01) A61P 29/00 (2006.01) C07D 207/16 (2006.01) C07D 211/60 (2006.01) C07D 241/04 (2006.01) C07D 241/24 (2006.01) C07D 295/185 (2006.01) C07D 295/205 (2006.01)

Patent

CA 2481879

Novel hydroxamic acid derivatives, e.g., of formula (I), wherein R1, R2, R3 and R4 are as defined, are found to be useful as pharmaceuticals, e.g., for the suppression of TNF release and the treatment of autoimmune and inflammatory diseases, e.g., multiple sclerosis and rheumatoid arthritis. Methods of making the compounds, novel intermediates, and pharmaceutical compositions comprising the compounds are provided.

L'invention porte sur de nouveaux dérivés de l'acide hydroxamique par exemple de formule (I) dans laquelle: R¿1?, R¿2?, R¿3? et R¿4? sont définis dans la description, et qui s'avèrent utiles comme produits pharmaceutiques, par exemple: pour la suppression de la libération du TNF et le traitement de maladies auto-immunes et inflammatoires telles que la sclérose en plaques et la polyarthrite rhumatoïde. L'invention porte également sur des procédés d'obtention: desdits composés, de nouveaux intermédiaires, et de compositions pharmaceutiques comprenant les composés.

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