Hydroxamic acid derivatives as inhibitors of the production...

C - Chemistry – Metallurgy – 07 – C

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C07C 259/06 (2006.01) A61K 31/16 (2006.01) A61K 31/165 (2006.01) C07C 237/22 (2006.01) C07C 323/60 (2006.01) C07D 207/404 (2006.01) C07D 215/14 (2006.01) C07D 271/06 (2006.01) C07D 277/24 (2006.01) C07D 311/58 (2006.01) C07D 333/54 (2006.01) C07D 333/60 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2335513

Compounds of formula (I) wherein: R is methyl substituted by one to three groups selected from alkyl, aryl, alkenyl, and alkynyl; n is 0 or 1; R1 is arylmethyl or heterocyclylmethyl; R2 is alkyl, alkenyl, cycloalkyl or cycloalkenyl; and R3 is hydrogen, alkyl, alkenyl, alkynyl or aryl; are useful in the treatment of disorders mediated by s-CD23.

Les composés correspondant à la formule (I), formule dans laquelle R représente un méthyle substitué par un à trois groupes sélectionnés dans le groupe constitué par un alkyle, un aryle, un alcényle et un alcynyle, la valeur de n étant 0 ou 1, R?1¿ représentant un aryl-méthyle ou un hétérocyclylméthyle, R?2¿ représentant un alkyle, un alcényle, un aryle, un cycloalkyle ou un cycloalcényle et R?3¿ représentant un hydrogène, un alkyle, un alcényle un alcynyle ou un aryle, s'avèrent des plus utiles s'agissant de traiter des troubles provoqués par la protéine s-CD23.

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