Hydroxamic acid derivatives as metalloproteinase inhibitors

Details Hydroxamic acid derivatives as metalloproteinase inhibitors Hydroxamic acid derivatives as metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 323/41 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/22 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 237/22 (2006.01) C07C 259/06 (2006.01) C07C 317/28 (2006.01) C07C 317/50 (2006.01) C07C 323/60 (2006.01) C07D 207/27 (2006.01) C07D 209/48 (2006.01) C07D 307/16 (2006.01) C07D 309/06 (2006.01) C07D 333/24 (2006.01)

Patent

CA 2181709

Matrix metalloproteinase inhibiting compounds of formula (I), wherein X is a - CO2H or -CONHOH group; and one of the groups proximate to the amide bonds is a steric bulky group, showing enhanced oral absorption.

Composés inhibiteurs de métalloprotéinase matricielle représentés par la formule (I) dans laquelle X représente un groupe -CO¿2?H ou -CONHOH, et un des groupes à proximité des liaisons amide est un groupe stérique volumineux présentant une absorption orale accrue.

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