Hydroxamic acid derivatives as metalloproteinase inhibitors

Details Hydroxamic acid derivatives as metalloproteinase inhibitors Hydroxamic acid derivatives as metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 259/06 (2006.01) A61K 31/16 (2006.01) A61K 31/33 (2006.01) C07C 323/41 (2006.01) C07D 207/27 (2006.01) C07D 213/56 (2006.01) C07D 225/02 (2006.01) C07D 231/12 (2006.01) C07D 233/61 (2006.01) C07D 277/30 (2006.01) C07D 333/24 (2006.01) C07D 333/60 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2140626

Compounds of formula (I) have matrix metalloproteinase inhibitory activity, wherein R2 represents a group R6-A- wher- ein A represents a divalent straight or branched, saturated or unsaturated hydrocarbon chain of up to 6 C atoms which may be interrupted by an O or S atom, and R6 represents hydrogen or an optionally substituted phenyl, cycloalkyl or cycloalke- nyl group; R3 represents a group R7-(B)n- wherein n is 0 or 1, B represents a divalent straight or branched, saturated or un- saturated hydrocarbon chain of up to 6 C atoms which may be interrupted by an O or S atom, and R7 is -CONHOH, car- boxyl, esterified or amidated carboxyl, cycloalkyl, cycloalkenyl, heterocyclyl, phenyl, naphtyl, or substituted phenyl or naphtyl in which the substituent(s) are selected from phenyl, hydroxy, C1-C6 alkoxy, benzyloxy, or R8-(C=O)-(C1-C6al- kyl)-O- wherein R8 is hydroxy, amino, or an amino acid residue linked via an amide bond; or (except when n=0) R7 is hy- drogen; R4 represents hydrogen or methyl; R5 represents hydrogen, C1-C6 alkyl or a group D-(C1-C6 alkyl) wherein D re- presents hydroxy, (C1-C6)alkoxy, (C1-C6)alkylthio, acylamino, optionally substituted phenyl, or a heterocyclic group, NH2, or a mono- or di-(C1-NC6 alkyl) amine or a heterocyclic group; or R3 and R5 taken together represent a divalent, saturated or unsaturated hydrocarbon chain of from 8-14 C atoms, which may be interrupted by an O, S or N heteroatom, or a salt, solvate or hydrate thereof, provided that R3 is not the characteristic side chain of a natural alpha-amino acid, or the charac- teristic side chain of a natural alpha-amino acid in which any functional substituents are protected, any amino groups are acylated, and any carboxyl groups are esterified.

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