C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/26 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 231/08 (2006.01) C07D 233/78 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2244903
The present invention provides novel hydroxamic acid derivatives represented by the compound of formula (I), or pharmaceutical acceptable salts thereof, wherein the compounds of the present invention inhibit various enzymes from the matrix metalloproteinase family, including collagenase, stromelysin, and gelatinase, and hence are useful for the treatment of matrix metallo endoproteinase diseases such as osteoarthrits, rheumatoid arthritis, septic arthritis, osteopenias such as osteoporosis, tumor metastasis (invasion and growth), periodontitis, gingivitis, corneal ulceration, dermal ulceration, gastric ulceration, and other diseases related to connective tissue degradation.
La présente invention concerne de nouveaux dérivés d'acide hydroxamique représentés par le composé de la formule générale (I) ou ses sels, acceptables sur le plan pharmaceutique. Les composés de l'invention inhibent différentes enzymes de la famille des métalloprotéinases matricielles, en particulier la collagénase, la stromélysine et la gélatinase. Ils sont donc utiles dans le traitement de maladies associées aux métalloendoprotéinases matricielles, telles que l'arthrose, la polyarthrite rhumatoïde, l'arthrite aiguë suppurée, les ostéopénies telles que l'ostéoporose, les métastases malignes (invasion et croissance) la périodontite, la gingivite, les ulcérations de la cornée, les ulcérations dermiques, les ulcérations gastriques et d'autres maladies liées à la dégradation du tissu conjonctif.
Macrae & Co.
Pharmacia & Upjohn Company
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