Hydroxamic acid derivatives of 7-[(2-amino-4- thiazolyl...

Details Hydroxamic acid derivatives of 7-[(2-amino-4- thiazolyl... Hydroxamic acid derivatives of 7-[(2-amino-4- thiazolyl...

C - Chemistry, Metallurgy

07

D

260/104.1

C07D 501/20 (2006.01) C07D 209/48 (2006.01) C07D 277/20 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1154434

GG281 Abstract HYDROXAMIC ACID DERIVATIVES OF 7-[(2-AMINO-4-THIAZOLYL)- OXIMINO] CEPHALOSPORINS A compound of the formula Image wherein R is hydrogen, alkali metal, Image lower alkyl or Image ; Si(CH3)3, p-methoxybenzyl, diphenylmethyl, benzyl, trichloroethyl or lower alkyl R1 is hydrogen or methyl; R2 is hydrogen or methyl; R3 is hydrogen, lower alkyl or lower alkylphenyl; R4 is hydrogen, -OCONH2, Image Image Image or Image lower alkyl; CG281 R7 is hydrogen or lower alkyl; R8 is hydrogen or -CONH2; R9 is hydrogen, lower alkyl, Image , Image or -(CH2)p-N-(lower alkyl)2; R10 is hydrogen or lower alkyl; R11 is hydrogen, sodium or potassium; n is 1, 2, 3.or 4; m is 0, 1 or 2; p is 1, 2, 3 or 4. The compounds are useful as anti- bacterial agents.

372887

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