C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/549.45, 260/
C07D 307/58 (2006.01) A61K 31/15 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/21 (2006.01) A61K 31/335 (2006.01) A61K 31/34 (2006.01) A61K 31/355 (2006.01) C07D 307/36 (2006.01) C07D 307/38 (2006.01) C07D 307/52 (2006.01) C07D 307/54 (2006.01) C07D 307/71 (2006.01)
Patent
CA 1043800
ABSTRACT OF THE DISCLOSURE New compounds of the general formula (I) Image (I) wherein X represents a lower cycloalkylidene group or a methyl- ene group having one or more substituents selected from the group consisting of phenyl, mono- or dinitro- phenyl, a furyl group and a nitro furyl group; R represents hydrogen or a C1-5 alkyl group; and Y represents a C1-C15 alkyl group, a benzyl group or a halobenzyl group are prepared (a) by reacting a compound of the general formula (II) or an acid addition salt thereof, Image (II) wherein n and Y have the above meanings, with an oxo compound of the general formula (IV), X = O (IV) wherein X has the above meaning, or (b) by reacting a Schiff- base of the general formula (III) Image (III) wherein R and X have the above meanings and R' represents hydro- gen or a phenyl group having one or more halogen or nitro sub- stitutent with a hydroxylamine derivative of the general formula (V) or an acid addition salt thereof, H2N - O - Y (V) wherein Y has the above meaning. The new compounds of the formula I possess a tuberculostatic effect and can be used in the treatment of tuberculosis.
214945
Dancsi Lajos
Fekete Gyorgy
Kisfaludy Lajos
Patthy Agnes
Szabo Istvan
Na
Richter Gedeon Vegyeszeti Gyar Rt
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