Hydroxamic acid esters and pharmaceutical use thereof

Details Hydroxamic acid esters and pharmaceutical use thereof Hydroxamic acid esters and pharmaceutical use thereof

C - Chemistry, Metallurgy

07

C

C07C 259/10 (2006.01) A61K 31/165 (2006.01) C07D 213/84 (2006.01) C07D 401/12 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2549242

The invention relates to compounds of general formula I wherein D, E, F, G, W, Y R1, A, R9, X, B, R8 are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use-alone or in combination with one or more other pharmaceutically active compounds- in therapy, for treating diseases associated with deregulated angiogeneseI, such as cancer

L'invention concerne des composés de formule générale (I), dans cette formule, D, E, F, G, W, Y R¿1?, A, R¿9?, X, B, R¿8? sont définis dans la description, ainsi que des sels, des hydrates, ou des solvates pharmaceutiquement acceptables des composés de l'invention, à utiliser seuls ou combinés à au moins un autre composé pharmaceutiquement actif, dans une thérapie, pour traiter des maladies associées à une angiogénèse dérégulée, notamment un cancer.

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