C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2297988
Selected novel hydroxamic acid substituted fused heterocyclic compounds of formula (I) are effective for prophylaxis and treatment of inflammation, tissue degradation and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflammation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes (I).
Cette invention concerne de nouveaux composés hétérocycliques hybrides et substitués par de l'acide hydroxamique qui correspondent à la formule (I) et sont efficaces pour la prophylaxie et le traitement d'inflammations, de la dégradation tissulaire et des affections apparentées. Cette invention concerne de nouveaux composés, des analogues, des promédicaments et leurs sels pharmaceutiquement acceptables, des compositions pharmaceutiques ainsi que des procédés pour la prophylaxie et le traitement d'inflammations, de la dégradation tissulaire et des affections apparentées. L'invention se rapporte également à des processus permettant d'obtenir ces composés ainsi qu'à des produits intermédiaires utiles dans ces processus (I).
Hummel Conrad
Hwang Chan Kou
Koch Kevin
Russo-Rodriguez Sandra E.
Thomson David S.
Amgen Inc.
Gowling Lafleur Henderson Llp
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