Hydroxamic acids and process for making same

Details Hydroxamic acids and process for making same Hydroxamic acids and process for making same

A - Human Necessities

61

K

260/549.47

A61K 31/195 (2006.01)

Patent

CA 1095532

ABSTRACT OF THE DISCLOSURE New and useful phenylalkylhydroxamic acids are disclosed of the formula Image wherein: (a.) R is selected from the group consisting of alkyl or alkoxy of one to six carbon atoms, alkenyloxy of two to six carbon atoms, alkyl of one to six carbon atoms, and benzyloxy, (b.) R1 and R2 are each selected from the group consisting of hydrogen, alkoxy of one to six carbon atoms, alkenyloxy of two to six carbon atoms, alkyl from one to six carbon atoms, and benzyloxy; (c.) R3 and R4 are selected from the group consisting of hydro- - gen or alkyl of one to six carbon atoms; (d.) R5 is hydrogen or R5 together with R3 or R4 represents methylene; and (e.) n signifies the number 0 or 1, and non-toxic salts thereof, which novel compounds exert a pronounced in- hibition of blood platelet aggregation, and accelerate the disaggregation of platelet aggregates already formed.

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