Hydroxamic acids of 7-oxabicycloheptane substituted ethers

Details Hydroxamic acids of 7-oxabicycloheptane substituted ethers Hydroxamic acids of 7-oxabicycloheptane substituted ethers

C - Chemistry, Metallurgy

07

D

167/245, 260/363

C07D 493/08 (2006.01) A61K 31/34 (2006.01)

Patent

CA 1314290

Abstract HYDROXAMIC ACIDS OF 7-OXABICYCLOHEPTANE SUBSTITUTED ETHERS Hydroxamic acids of 7-oxabicycloheptane substituted ether prostaglandin analogs are provided having the structural formula Image wherein Q is -CH2-A-(CH2)m- or (CH2)t; X is Image or O, Y is O or Image , and including all stereoisomers thereof. The compounds are inhibitors of .DELTA.5-lipoxy- genase and inhibitors of prostaglandin and leukotriene biosynthesis and as such are useful, for example, as anti-allergy and antiinflammatory agents and also as antipsoriatic agents.

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