Hydroxamic and carboxylic acid derivatives

Details Hydroxamic and carboxylic acid derivatives Hydroxamic and carboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 295/22 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/495 (2006.01) A61P 1/02 (2006.01) A61P 1/04 (2006.01) A61P 1/14 (2006.01) A61P 7/02 (2006.01) A61P 7/04 (2006.01) A61P 9/00 (2006.01) A61P 9/08 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/02 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 25/06 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 27/16 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2

Patent

CA 2317455

For the treatment of cancer, inflammation and other conditions associated with matrix metalloproteinases or that are mediated by TNF .alpha. or enzymes involved in the shedding of L-selectin, CD23, the TNF receptors, IL-1 receptors or IL-6 receptors, compounds are of general formula (I) B-X-(CH2)m- (CR1R2)n-W-COY.

L'invention concerne de nouveaux composés comprenant des dérivés d'acide carboxylique et hydroxamique utilisés pour traiter le cancer, une inflammation et d'autres états associés aux métalloprotéinases matricielles ou causés par TNF .alpha., ou par des enzymes intervenant dans l'élimination de la L-sélectine, des récepteurs TNF, des récepteurs IL-1 ou des récepteurs IL-6. Ces nouveaux composés sont représentés par la formule (I) B-X-(CH¿2?)¿m?-(CR?1¿R?2¿)¿n?-W-COY.

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