Hydroxamic and carboxylic acid derivatives

Details Hydroxamic and carboxylic acid derivatives Hydroxamic and carboxylic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 311/21 (2006.01) A61K 31/18 (2006.01) A61K 31/343 (2006.01) A61K 31/445 (2006.01) A61K 31/472 (2006.01) A61K 31/4965 (2006.01) A61P 7/00 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07C 311/13 (2006.01) C07D 211/96 (2006.01) C07D 213/74 (2006.01) C07D 215/58 (2006.01) C07D 295/26 (2006.01) C07D 307/81 (2006.01)

Patent

CA 2367963

Compounds (many of which are new) that have utility in the treatment of a condition associated with matrix metalloproteinase, ADAM or ADAM-TS enzymes, a condition that is mediated by TNF .alpha. or a condition involving a membrane- shedding event that is mediated by a metalloproteinase, are of formula (I): (B)2N-X-(CH2)m-W-(CR1R2)n-COY, wherein n= 0 or 1; m =0 or 1; X is S(O)1-2; Y is OH or NHOH; W is aryl or heteroaryl; and the other groups are as defined herein.

L'invention concerne des composés (dont bons nombres sont nouveaux) utilisés dans le traitement d'un trouble associé à une métalloprotéinase matricielle, aux enzymes ADAM ou ADAM-TS, d'un trouble induit par TNF .alpha.ou d'un trouble qui occasionne une élimination du virus des membranes induit par la métalloprotéinase. Lequels composés correspondent à la formule suivante: (B)¿2?N-X-(CH¿2?)¿m?-W-(CR?1¿R?2¿)¿n?-COY(I) dans laquelle n= 0 ou 1; m =0 or 1; X représente S(O)¿1-2?; Y représente OH ou NHOH; W représente aryle or hétéroaryle; n = 0 ou 1; m = 0 ou 1; X est S(O)¿1-2?; Y est OH ou NHOH; et les autres groupes sont tel que définis dans le descriptif.

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