Hydroxamic and carboxylic acid derivatives

Details Hydroxamic and carboxylic acid derivatives Hydroxamic and carboxylic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 309/08 (2006.01) A61K 31/35 (2006.01) C07C 309/08 (2006.01) C07C 311/44 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2317476

Use of a compound for the manufacture of a medicament for the treatment or prevention of a condition associated with matrix metalloproteinases or that is mediated by TNF .alpha. or enzymes involved in the shedding of L-selectin, CD23, the TNF receptors, IL-1 receptors or IL-6 receptors, wherein the compound is of the formula (I): B-X-(CH2)n-CR2R3-CR4R5-COY.

L'invention concerne l'utilisation d'un composé pour la fabrication d'un médicament se prêtant au traitement ou à la prévention d'un état qui est associé aux métalloprotéases de type matriciel ou bien dont la médiation est assurée par le TNF .alpha. ou par des enzymes intervenant dans la diffusion de la L-sélectine, du CD23 ainsi que des récepteurs du TNF et d'IL-1 ou d'IL-6. Ledit composé est représenté par la formule générale (I): B-X-(CH¿2?)¿n?-CR?2¿R?3¿-CR?4¿R?5¿-COY.

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