Hydroxamic and carboxylic acid derivatives having mmp and...

Details Hydroxamic and carboxylic acid derivatives having mmp and... Hydroxamic and carboxylic acid derivatives having mmp and...

C - Chemistry, Metallurgy

07

C

C07C 317/44 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/50 (2006.01) C07D 207/404 (2006.01) C07D 207/48 (2006.01) C07D 209/48 (2006.01) C07D 211/54 (2006.01) C07D 213/56 (2006.01) C07D 213/71 (2006.01) C07D 215/36 (2006.01) C07D 233/74 (2006.01) C07D 233/84 (2006.01) C07D 237/14 (2006.01) C07D 237/32 (2006.01) C07D 277/26 (2006.01) C07D 295/26 (2006.01) C07D 307/5

Patent

CA 2263154

The invention concerns hydroxamic acid and carboxylic acid derivatives of formulae (I): B-X-(CH2)n-CHR1-(CH2)m-CONHOH and (Ia): B-S(O)1-2-(CH2)n-CHR1- (CH2)m-COOR2, in which X is O, NR3 or S(O)0-2, and the other variables have the definitions given in the claims, having MMP and TNF inhibitory activity.

La présente invention se rapporte à des dérivés de l'acide hydroxamique et de l'acide carboxylique, dotés d'une activité inhibitrice vis à vis des métalloprotéases matricielles (MMP) et du facteur de nécrose des tumeurs (TNF). Ces dérivés sont représentés par les formules (I): B-X-(CH¿2?)¿n?-CHR?1¿-(CH¿2?)¿m?-CONHOH et (Ia): B-S(O)¿1-2?-(CH¿2?)¿n?-CHR?1¿-(CH¿2?)¿m?-COOR?2¿, dans lesquelles X est O, NR¿3? ou S(O)¿0-2?, les autres variables étant définies dans les revendications.

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