C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/16 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61P 35/00 (2006.01) C07C 57/58 (2006.01) C07C 61/40 (2006.01) C07C 211/50 (2006.01) C07C 211/52 (2006.01) C07C 233/22 (2006.01) C07C 233/31 (2006.01) C07C 233/43 (2006.01) C07C 233/44 (2006.01) C07C 233/51 (2006.01) C07C 271/28 (2006.01) C07D 213/75 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 233/68 (2006.01) C07D 233/70 (2006.01) C07D 233/90 (2006.01) C07D 235/12 (2006.01) C07D 239/46 (2006.01) C07D 3
Patent
CA 2513436
A compound having the following formula (I): wherein R1 is N-containing heterocyclic ring optionally substituted with one or more suitable substituent(s), R2 is hydroxyamino, R3 is hydrogen or a suitable substituent, L1 is -(CH2#191)n#191- (wherein n is an integer of 0 to 6) optionally substituted with one or more suitable substituent(s), wherein one or more methylene(s) may be replaced with suitable heteroatom(s), and L2 is lower alkenylene, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.
L'invention concerne un composé représenté par la formule (I) ou un sel dudit composé. Dans cette formule, R?1¿ est un noyau hétérocyclique contenant N éventuellement substitué par un ou plusieurs substituants, R?2¿ est hydroxyamino, R?3¿ est hydrogène ou un substituant approprié, L?1¿ est (CH¿2?)¿n?- (où n est un nombre entier compris entre 0 et 6) éventuellement substitué par un ou plusieurs substituants, un ou plusieurs méthylènes pouvant être remplacés par un ou plusieurs hétéroatomes appropriés, et L?2¿ est alcénylène inférieur. Ledit composé est utile comme inhibiteur de l'histone désacétylase.?¿
Ishibashi Naoki
Kamijo Kazunori
Satoh Shigeki
Urano Yasuharu
Astellas Pharma Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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