Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods

Details Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4745 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2628131

1H-Imidazo[4,5-c]quinolin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

La présente invention concerne des 1H-imidazo[4,5-c]quinolin-4-amines ayant un substituant hydroxy, alcoxy, hydroxyalcoxy, ou alcoxyalcoxy à la position 2, des compositions pharmaceutiques contenant ces composés, des procédés de préparation des composés, des intermédiaires, et des procédés d'utilisation de ces composés en tant qu'immunomodulateurs, pour induire la biosynthèse de cytokine chez des animaux et dans le traitement de maladies y compris de maladies virales et néoplasiques.

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