Hydroxy and ether-containing oxyalkylene esters and uses...

Details Hydroxy and ether-containing oxyalkylene esters and uses... Hydroxy and ether-containing oxyalkylene esters and uses...

A - Human Necessities

61

K

A61K 31/22 (2006.01) A61K 31/235 (2006.01) C07C 69/02 (2006.01) C07C 69/612 (2006.01) C07C 69/708 (2006.01) C07C 69/96 (2006.01)

Patent

CA 2283173

This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating blood disorders such as anemias, immunomodulation, enhancing recombinant gene expression, treating insulin-dependent patients, treating cystic fibrosis patients, inhibiting telomerase activity, treating virus-associated tumors, especially EBV-associated tumors, augmenting expression of tumor suppressor genes, inducing tolerance to antigens, or treating, preventing or ameliorating protozoan infection or inhibiting histone deacetylase in cells. The compositions of the invention are to and the methods of the invention use hydroxy and ether-containing oxyalkylene esters.

L'invention concerne des compositions et des procédés de traitement, de prévention, et de lutte contre le cancer et d'autres maladies prolifératives, ainsi que des procédés qui favorisent la cicatrisation, traitent les ulcérations cutanées, les troubles gastro-intestinaux et les dysfonctionnements sanguins tels que l'anémie, et modulent la réponse immunitaire. Ces procédés favorisent également l'expression génique recombinée, traitent les patients insulinodépendants et les patients atteints de mucoviscidose, inhibent l'activité télomérase, traitent les tumeurs virales, notamment les tumeurs liées au virus Epstein-Barr, augmentent l'expression de gènes suppresseurs de tumeur, améliorent la tolérance aux antigènes, ou traitent, préviennent ou luttent contre les protozooses, ou inhibent l'histone déacétylase cellulaire. Les compositions et les procédés de cette invention utilisent des esters d'oxyalkylène hydroxy et renfermant un éther.

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